Vitiligo is a skin condition with patches of white color occurring on any area of the human body and several treatment approaches are recommended in main stream medicine as well as alternative modes of treatments. Patients suffer psychosocial stress due to social rejection and consequent loss of self-esteem and self-confidence. This paper presented an in-depth case study of a 29-year-old female vitiligo patient, who used and practiced Yoga Prana Vidya (YPV) protocols for self-healing. Case series method is used examining full case papers and narration of major events by the patient on what worked well for her using YPV system intervention. The patient persistently healed herself with 2 to 4 sessions a day and within a time span of 11⁄2 months her all the vitiligo patches had healed almost by 50%. After a year of continuing the YPV intervention, the recovery was sustained and further recovery of 30% was seen as she continued with her practices of YPV techniques. As a result, she regained self-esteem and self-confidence overcoming the accumulated psychosocial stress. During this period, she was not taking any medications, but only doing self-healing using YPV protocols. The overall improvement over a period of one year and three months was nearly 80% and a complete life changing experience with self-acceptance after a prolonged traumatic phase in life. YPV system is proving to be a versatile approach to resolving a variety of health issues, as is evident from the published literature.